Multiomics analysis of canine myocardium after circumferential pulmonary vein ablation: Effect of NPY on long-term reinduction of atrial fibrillation

In this study,We established a long-term model of beagle canines after circumferential pulmonary vein ablation (CPVA). The transcriptome and proteome were obtained using high-throughput sequencing and TMT-tagged LC‒MS/LC analysis. Differentially expressed genes and proteins were screened and enriched, and the effect of fibrosis was found and verified in tissues Beagles underwent thoracotomy in the right fourth intercostal space, followed by circumferential pulmonary vein catheter ablation(CPVA). After 6 months of feeding, bullseye atrial muscle tissues were collected (CPVA:Control=5:5).