The loci of active HERV-H elements in colon cancer cell lines.

*Two adjacent HERV-H elements at 1p32.3 were combinedly active by making use of 5′ LTR of the first HERV-H and 3′ LTR of the second one (representative transcript sequence JK017392).
**The elements located at 16q24.1 and 19q13.31 are also actively transcribed in both tumor and adjacent normal colon tissues, while the one located at 20p12.1 is active in tumor tissue.
***Open reading frames (ORFs) were predicted by the online program ORF Finder and putative peptide sequences were subjected to Blastp search against the Non-redundant protein sequences at http://www.ncbi.nlm.nih.gov/. Only predicted ORFs≥303 nt (peptide sequence ≥100 aa) and with Blastp matches are included. Gag, group-specific antigen; RT, Reverse transcriptase; CREB5, cAMP response element-binding protein 5.