Crystal structure of Trastuzumab Fab conjugated to Linker-Payload

Crystal structure of Trastuzumab Fab conjugated to Linker-Payload Descriptor: COBALT (II) ION, N-({[4-({N-[3-(2,5-dioxopyrrolidin-1-yl)propanoyl]-L-alanyl-L-alanyl}amino)phenyl]methoxy}carbonyl)-N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, Trastuzumab Heavy Chain, ... Authors: Jaime-Garza, M, Noland, C.L, Gabelli, S.B. Deposit date: 2025-10-30 Release date: 2025-12-24 Last modified: 2026-01-14 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Structural Characterization of Linker Shielding in ADC Site-Specific Conjugates. Pharmaceutics, 17, 2025