DNA-methylation profiling of Whole blood genomic DNAs collected from participants of Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Homo sapiens

Study the association of DNA-methylation and metabolic memory by examing DNA-methylation alternation between cases (received conventional therapy in DCCT and showing retinopathy or albuminuria progression at EDIC year-10) and Controls (in DCCT intensive treatment group and did not have retinopathy or nephropathy progression during EDIC). Overall design: Bisulphite converted DNA from the 63 whole blood samples (32 Cases and 31 Controls) were hybridised to the Illumina Infinium HumanMethylation450 Beadchip arrays.