Oxidative stress (OS) and inflammation play pivotal roles in retinal pigment epithelium (RPE) degeneration and age-related macular degeneration (AMD) pathogenesis. Interleukin 17 (IL17) signaling is a
aFrequency of effective allele in European-ancestry samples. bFrequency of effective allele in Singapore-based samples. Notes: Results for SNPs rs9332739, rs9380272, rs641153, rs1999930 and rs2230199
To explore whether IL-4 could exert a novel protective role for RPE damage and attenuate the pathogenesis of dry age-related macular degeneration (AMD), we established a retinal degeneration model of
