Supplementary Material for: Rare synchronous lung cancers in a non-smoker with EGFR and MET alterations: A Case Report

Introduction: Lung cancer is the second most common cancer but synchronous lung cancer is rare and challenging to treat. Case presentation: We report the case of an 80-year-old female patient who presented with 2 lung lesions with primary tumor characteristics which, after histological sampling, revealed squamous cell carcinoma and synchronous adenocarcinoma. NGS analysis revealed a MET Exon 14 Skipping mutation in the squamous cell carcinoma and an EGFR mutation in the adenocarcinoma. Capmatinib and stereotactic radiotherapy were started on the adenocarcinoma with good clinical response. Capmatinib treatment had to be discontinued due to stage 3 edema of the lower limbs, after which a left lobectomy was performed. The patient is currently considered to be in remission. Conclusion: This case highlights the need for histological analysis of every lung lesion with primary tumor characteristics, as well as for NGS analysis in search of specific mutations enabling the introduction of targeted therapies.