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Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners

ChEBI2011-01-10 更新2026-07-21 收录

巨核细胞分化

转录因子网络

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Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners

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2011-01-10

巨核细胞分化

依赖性基因表达

The molecular regulation of megakaryocytic differentiation is poorly understood. Using a myelogenous leukemia cell line, K562, which can partly recapitulate the process in response to phorbol 12-myri

NIAID Data Ecosystem100

Megakaryocyte lineage development is controlled by modulation of protein acetylation

巨核细胞分化

蛋白质乙酰化与去乙酰化

Treatment with lysine deacetylase inhibitors (KDACi) for haematological malignancies, is accompanied by haematological side effects including thrombocytopenia, suggesting that modulation of protein ac

NIAID Data Ecosystem80

HIC2 represses BCL11A transcription to regulate hemoglobin switching during development (RNA-Seq). HIC2 represses BCL11A transcription to regulate hemoglobin switching during development (RNA-Seq)

血红蛋白调控

转录因子网络

The switch from fetal to adult hemoglobin production has been studied in great depth in part because of its relevance to the treatment of hemolobinopathies. Transcription factor BCL11A, which is essen

NIAID Data Ecosystem50

Inhibition of O-GlcNAcylation via O-GlcNAc transferase fosters megakaryopoiesis and induces thrombopoiesis

巨核细胞分化

血小板生成

We report that cellular O-GlcNAcylation levels decline along the course of megakaryocyte (MK) differentiation from human-derived hematopoietic stem and progenitor cells (HSPCs) and that inhibition of

NIAID Data Ecosystem90

Data for: Unequal distribution of genes and chromosomes refers to nuclear diversification in the binucleated Giardia intestinalis.

寄生虫基因组

巨核细胞分化

The single-celled parasite Giardia intestinalis (Diplomonadida) has two equally sized nuclei in one cell. The nuclei have been considered identical. We have previously shown that they contain differen

NIAID Data Ecosystem60

Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners

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