Regioselective Chlorolactonization of Styrene-Type Carboxylic Esters and Amides via PhICl<sub>2</sub>‑Mediated Oxidative C–O/C–Cl Bond Formations
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
A facile method employing styrene-type carboxylic esters or amides in the presence of PhICl2 in CH3CN was developed to achieve the synthesis of 6-endo products 3,4-dihydroisocoumarins or 3,4-dihydroisocoumarin-1-imines in good to high yields. This metal-free regioselective intramolecular chlorolactonization process was proposed to involve a PhICl2-mediated oxidative C–O bond formation followed by C–Cl bond formation.
创建时间：
2019-09-17
