X-ray co-crystal structure of compound 8 bound to human Mcl-1
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X-ray co-crystal structure of compound 8 bound to human Mcl-1 Descriptor: (4S,11E,17R)-6'-chloro-17-hydroxy-14-methyl-15-oxo-3',4',8,9,10,13,14,15,16,17-decahydro-2'H,3H,5H,7H-spiro[1,18-(ethanediylidene)[1,4]oxazepino[4,3-a][1,8]diazacyclopentadecine-4,1'-naphthalene]-17-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 Authors: Huang, X, Whittington, D. Deposit date: 2019-09-19 Release date: 2019-12-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an alpha-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere. J.Med.Chem., 62, 2019
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2019-09-19
