BT20 (TNBC) cells were cultured with either DMSO (v/v%) or Erlotinib (10uM) for 24 hours to observe differential expression changes between conditions. CAS-9 expressing BT20 (TNBC) cells were transduc

NIAID Data Ecosystem50

DNA polymerase β is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts

DNA损伤修复机制

酶功能验证

The repair of oxidative base lesions in DNA is a coordinated chain of reactions that includes removal of the damaged base, incision of the phosphodiester backbone at the abasic sugar residue, incorpor

PubMed Central2001-12-03 更新10

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

DNA损伤修复机制

MRE11

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

NIAID Data Ecosystem70

Polymerase ? and mismatch repair cooperatively determine the mutagenicity of a methylating agent

DNA损伤修复机制

甲基化剂致突变性

We characterised genome-wide mutations induced by the O6-dG-methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in mouse embryonic fibroblasts, deficient for the Pol ? catalytic subunit REV3

NIAID Data Ecosystem50

Whole Genome CRISPR screen in SUM149 cells

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