Chemical Structure and Shape Enhance MR Imaging-Guided X‑ray Therapy Following Marginative Delivery

Ineffective
site-specific delivery has seriously impeded the efficacy
of nanoparticle-based drugs to a disease site. Here, we report the
preparation of three different shapes (sphere, scroll, and oblate)
to systematically evaluate the impact of the marginative delivery
on the efficacy of magnetic resonance (MR) imaging-guided X-ray irradiation
at a low dose of 1 Gy. In addition to the shape effect, the therapeutic
efficacy is investigated for the first time to be strongly related
to the structure effect that is associated with the chemical activity.
The enhanced particle–vessel wall interaction of both the flat
scroll and oblate following margination dynamics leads to greater
accumulation in the lungs, resulting in superior performance over
the sphere against lung tumor growth and suppression of lung metastasis.
Furthermore, the impact of the structural discrepancy in nanoparticles
on therapeutic efficacy is considered. The tetragonal oblate reveals
that the feasibility of the charge-transfer process outperforms the
orthorhombic scroll and cubic sphere to suppress tumors. Finally,
surface area is also a crucial factor affecting the efficacy of X-ray
treatments from the as-prepared particles.