Gene expression of lymphoma tissues from FBW7 KO mice

During maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, developing lymphocytes may undergo malignant transformation and produce B-cell lymphomas. Emerging evidence shows that through the endothelial-hematopoietic transition, specialized endothelial cells called the hemogenic endothelium can differentiate into HSPCs. However, the contribution of genetic defects in hemogenic endothelial cells to B-cell lymphomagenesis has not yet been investigated. / Gene expression data was obtained using an Affymetrix GeneChip Mouse Gene 2.0 ST Array and mRNAs isolated from mesenteric lymph nodes (mLNs) from lymphoma-bearing Fbw7ΔEC mice and normal mLNs from WT mice (n = 3 biological replicates per group).