Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp<sup>3</sup>)–H Bonds with Alkyl Iodides
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We report an efficient method for the alkylation of γ-C(sp3)–H bonds of picolinamide-protected aliphatic amine substrates with primary alkyl iodides via palladium catalysis. Ag2CO3 and dibenzyl phosphate, (BnO)2PO2H, are critical promoters of this reaction. These reactions provide a convenient and straightforward method for the preparation of high-value N-containing products from readily available amine and alkyl iodide precursors.
创建时间：
2013-02-13
