JAAD Supplemental Material -Sports bras improve chest keloids but outcomes are dependent on breast size: a retrospective analysis

Supplemental Figure 1. Study design and flow chart of the medical records selection in two groups.

Supplemental Figure 2. Effect of sports bra and breast size on keloid score after the combination treatment.
(a) The keloid scores in without sports bra group are significantly worse than scores in with sports bras group at 1-year follow-up. (b-c) The large breast size group (BSS＜7.7) shows more significant improvement of keloid score when patients wear sports bras than the small breast size group (BSS＞7.7). (d) Larger size of the breast is correlated to the worse keloid score in both two groups according to simple Linear Regression. However, the positive association in without sports bra group is stronger compared to with sports bra group.

Supplemental Figure 3. Impact of time of keloid onset and age of patient on the treatment outcome.
The result shows that the keloid score is not statistically correlated to the time of keloid onset or the age of patients in both groups.

Supplemental Figure 4. The clinical pictures of patients in both groups before and one year after operation.
The patients in with sports bra group exhibit milder erythema and telangiectasia and smaller vertical width of lesion one year after treatment compared to patients in without sports bra group.

Supplemental Figure 5. The typical pathological features of one of included patients.
(a) Low-power view shows the collagen is separated by small bundles of sparsely cellular fibroblastic tissue and chronic inflammatory cells. (b) High-power view highlights typical broad, hyalinized, and eosinophilic “bubble gum” collagen fibers. In addition, the lack of epidermal appendages is noted on both low and high power. (a, hematoxylin-eosin, original magnification×40; b, H&E, original magnification×200)

补充图 1. 两组医疗记录选择的研究设计和流程图。

补充图 2. 运动型胸罩及乳房大小对联合治疗后瘢痕疙瘩评分的影响。
(a) 无运动型胸罩组的瘢痕疙瘩评分在 1 年随访时显著劣于佩戴运动型胸罩组的评分。(b-c) 乳房较大组（BSS＜7.7）在患者佩戴运动型胸罩时瘢痕疙瘩评分的改善更为显著，相较于乳房较小组（BSS＞7.7）。(d) 在两组中，乳房大小与瘢痕疙瘩评分呈正相关，但无运动型胸罩组的这种正相关相较于佩戴运动型胸罩组更为显著。

补充图 3. 瘢痕疙瘩发生时间及患者年龄对治疗效果的影响。
结果显示，两组中瘢痕疙瘩评分与瘢痕疙瘩发生时间或患者年龄均无统计学相关性。

补充图 4. 两组患者手术前后临床图片。
与未佩戴运动型胸罩组相比，佩戴运动型胸罩组患者在治疗 1 年后的红斑和蜘蛛痣症状更为轻微，且病变的垂直宽度更小。

补充图 5. 患者典型病理特征的描述。
(a) 低倍镜下可见胶原纤维被稀疏细胞纤维母细胞和慢性炎症细胞的小束所分隔。(b) 高倍镜下突出显示典型的宽阔、透明化和嗜酸性“泡泡糖”样胶原纤维。此外，在低倍和高倍镜下均观察到表皮附属物的缺失。（a，苏木精-伊红染色，原放大倍数×40；b，H&E 染色，原放大倍数×200）