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RNA-seq of cold-induced transcriptome changes in skeletal muscle of beta-adrenergic receptor knockout mice

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Exposure to cold temperatures is known to mimic the effects of exercise, protecting against obesity and improving metabolic health. Cold is known to act through the sympathetic nervous systems and -adrenergic signaling, but here we report that cold temperature can directly activate a variety of gene programs in muscle independent of -adrenergic signaling.

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