The global effect of aortic coarctation on carotid and renal pulsatile hemodynamics

Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. If left untreated, by the time individuals reach 50 years of age, the mortality rate can reach 90%. Previous studies have highlighted the adverse effects of CoA on local hemodynamics. However, no study has investigated the global hemodynamic effects of CoA in end-organ (brain and kidney) damage. Clinical studies have shown that coarctation acts as a reflection site, potentially damaging the hemodynamics of the brain and kidneys. Our goal in this study is to investigate the underlying mechanisms of these altered wave dynamics and their impacts on the pulsatile hemodynamics of end-organs. In this study, we use a physiologically accurate in-vitro experimental setup that simulates the hemodynamics of systemic circulation. Experiments are conducted across various cardiac outputs, heart rates, and coarctation degrees using aorta..., , , # Data from: The global effect of aortic coarctation on carotid and renal pulsatile hemodynamics

[https://doi.org/10.5061/dryad.6t1g1jx63](https://doi.org/10.5061/dryad.6t1g1jx63)

We have submitted our supplementary material and raw data corresponding to each figure.

This dataset includes:

* The carotid pressure waveforms for normal and different coarctation degrees
* The carotid & renal pulsatile power transmission for normal and different coarctation degrees for normal and low cardiac outputs
* The carotid & renal mean flowrate for normal and different coarctation degrees for normal and low cardiac outputs
* The carotid & renal pulsatile power transmission for different aortic stiffness for normal and severe coarctation
* The carotid & renal pulsatile power transmission for normal and different coarctation degrees across different heart rates
* Total, forward, and backward wave intensity profiles at carotid & renal arteries for normal and different coarctation degrees
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