A design of experiments (DoE) approach was taken to optimize purity and reaction yield of the final debenzylation and hydrochloride salt formation of IPI-926. The study involved a careful dissection o
XRD pattern of ES (oven dried state).;XRD pattern of ES (calcined at 900 degree Celsius).;TG characteristics of ES (oven dried);XRD pattern of Hap samples (condition 80 mesh and calcined at 700 degree
A methodology is presented that allows hazardous dipolar aprotic solvents used in the pharmaceutical processing industries to be replaced with solvent-pair mixtures that consist of a hydrogen-bond don
