Transcriptomic profiles of human aortic smooth muscle cell (HASMC) which exposed to M(con) or M(Hb) macrophage supernatant with osteogenic conponents supplementation

Vasclar calcification (VC) is concomitant with atherosclerosis. CD163+ M(Hb) macrophages at the site of intraplaque hemorrhage of advanced atherosclerosis provoke angiogenesis and microvascular permeability contributing plaque destabilazation. We investigated the role of CD163+ macrophage on the process of VC, and found CD163+ macrohpages inhibit VC through NFκB-induced hyaluronan synthase augmentation and subsequently promote the high-risk plaque development. Transcriptomic profiles of human aortic smooth muscle cell (HASMC) which exposed to M(con) or M(Hb) macrophage supernatant with osteogenic conponents supplementation for 6 hours were examined by ClariomTM S microarray.