Differential Expression Profile of MicroRNAs and Tight Junction in Lung Tissue of Rat with Mitomycin-C Induced Pulmonary Veno-Occlusive Disease

Pulmonary veno-occlusive disease (PVOD) is characterized by increased pulmonary vascular resistance. Currently, there is a lack of effective treatment. It is of great significance to explore molecular targets for treatment of the disease. This study investigated the differentially expressed profile of miRNAs and tight junction in the lung tissue of rats with mitomycin-C induced PVOD.肺静脉闭塞症（Pulmonary veno-occlusive disease, PVOD）以肺血管阻力升高为特征，目前尚缺乏有效的治疗手段，探索该疾病的治疗分子靶点具有重要意义。本研究针对丝裂霉素C（mitomycin-C）诱导的肺静脉闭塞症模型大鼠的肺组织，分析了微小RNA（miRNAs）与紧密连接（tight junction）的差异表达谱。