Supporting data for "STUDIES ON TRANSITION METAL-CATALYZED ASYMMETRIC REDUCTIONS AND REDUCTIVE AMINATIONS"

The dataset includes the general information and experimental details of the PhD thesis "STUDIES ON TRANSITION METAL-CATALYZED ASYMMETRIC REDUCTIONS AND REDUCTIVE AMINATIONS". The development of efficient methods to construct diverse chiral molecules is important to organic synthesis and medicinal chemistry. The related works the synthesis of chiral alcohols and amines are in this dataset. We established a broadly applicable synthesis of enantioenriched NH lactams through a one-pot asymmetric reductive amination/cyclization sequence of easily available keto acids/esters. Furthermore, an efficient and straightforward strategy to synthesize enantio-enriched N-unprotected α-amino acetals via ruthenium-catalyzed direct asymmetric reductive amination was then achieved. In addition, we also developed an asymmetric 1,2-reduction of cyclic α, β-unsaturated ketones to access various enantiomerically enriched cyclic allylic alcohols under mild conditions, catalyzed by in situ generated copper hydride ligated with (R)-DTBM-C3*-TunePhos.