RNA-Seq Analysis of TCDD-Elicited Changes in Circadian Hepatic Gene Expression in Male Mice. RNA-Seq Analysis of TCDD-Elicited Changes in Circadian Hepatic Gene Expression in Male Mice

Hepatic gene expression was examined every 3 hours for 24 hours following repeated exposure (every 4 days for 28 days) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). These data were used to examine the effect of repeated TCDD exposure on the circadian rhythmicity of hepatic gene expression in C57BL/6 male mice. Overall design: Three biological replicates for each timepoint (ZT0, ZT3, ZT6, ZT9, ZT12, ZT15, ZT18, ZT21) of TCDD and sesame oil vehicle.