Transcriptomes of human myometrium in labor reveals the increased molecular associated with inflammation under hypoxia stress. Transcriptomes of human myometrium in labor reveals the increased molecular associated with inflammation under hypoxia stress

Labor involves a variety of coordinated events across physiological and biochemical aspects, the molecular mechanism responsible for the transition of the myometrium from the quiescent to a contractile state remains indistinct.The global transcriptome in human non-labor and in labor myometrium was investigated through RNA sequencing (RNA-seq) to explore biological processes and pathways alterations during labor. The transcriptomic bioinformatics results showed that the up-regulated mRNAs increased inflammation under hypoxia stress in laboring myometrium. Overall design: mRNA, lncRNA profiles of human myometrium in labor and non-labor