Genome accessibilty (ATACseq) data in neruonal and non-neuronal cells from the putamen of human heroin abusers

The putamen plays a central role in ther regulation of reward, emotion, motivation and goal-directed behavior. Genome accessibility changes in this brain region are of crucial interest to understand the neurobiological underpinnings of heroin use disorder. Overall design: Human brains from apparent heroin overdose and normal control Caucasian subjects without head trauma were collected at autopsy with 24 hours of death. Cause of death was determined by forensic pathologist. Neuronal and non-neuronal (glial) cell populations were FACS-sorted based on NeuN expression.