Frequencies, by maximum severity, of local symptoms and systemic reactions possibly, probably or certainly related to vaccination, as a function of immunization route.

Tabulated values are numbers (percentages) of volunteers experiencing at least one reaction after any vaccination. Percentages do not add up to 100 because some volunteers had >1 symptom and/or reaction. All reactions resolved without sequelae within a median of 56 hours (interquartile range 9–304 hours). a95% confidence interval in intradermal (ID) arm:18 to 52% and in intramuscular (IM) arm: 17 to 49%; ID vs. IM P = 0.87. b95% confidence interval in ID arm:18 to 52% and in IM arm: 7 to 34%; ID vs. IM P = 0.12. cOther grade-2 local symptoms in the ID arm: local myalgia, injection-site vesicles. dOther grade-2 systemic reactions in the IM arm: conjunctivitis, fatigue and rhinitis; in the intradermal arm: flu-like syndrome.