Significantly enriched KEGG pathways altered by influenza infection of DC.

Approximately 25,000 peptides were detected with corresponding reporter ions (available in the PRIDE repository). (A) 7,520 confidently identified peptides from the stable isotopically labeled (SIL) and isobaric tagged (iTRAQ) proteomes were mapped to National Center for Biotechnology Information (NCBI) reference sequence accession numbers. (B-C) Confidently identified protein identifiers from the soluble and insoluble fractions were segregated into upregulated (B) or downregulated (C) based on 2-fold or greater abundances changes and submitted to DAVID for KEGG pathway analysis. Significantly enriched KEGG pathways are listed and gene symbols associated with NCBI accession numbers are provided along with corresponding KEGG class and subclass from the BRITE hierarchy (colored circles correspond to subclasses from Fig 1). (XLSX)