Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome

To examine the global responses to poly-GA aggregates in vivo, we used AAV to deliver the poly-GA DNA into mouse brains We performed RNA sequencing of the cortex of control and poly-GA mice (5-month-old) to analyze the differential gene expression profile Comparative gene expression profiling analysis of RNA-seq data for AAV-GFP and AAV-GFP-GA injected cortex.