LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2

Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 7S(8)-epoxy-17(R)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(R)-HDHA) to the trihydroxydocosahexaenoic acids 7(S), 8(R), 17(R)-triHDHA and 7(S), 16(R), 17(R)-triHDHA (AT-RvD1 and AT-RvD2 respectively) (Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).

白三烯A4水解酶（LTA4H）是一种单体、可溶性酶，利用Zn2+辅因子催化烯丙基环氧白三烯A4（LTA4）的羟基化反应（McGee & Fitzpatrick 1985）。LTA4H还能够催化7S(8)-环氧-17(R)-羟基二十二碳六烯酸（7S(8)-环氧-17(R)-HDHA）的水解，生成三羟基二十二碳六烯酸7(S), 8(R), 17(R)-triHDHA和7(S), 16(R), 17(R)-triHDHA（分别对应AT-RvD1和AT-RvD2）（Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002）。D-解救素具有抗炎、促进溶解和抗炎症反应的特性（即，它们介导白细胞清除而不引发炎症反应）（Serhan et al. 2008）。