DBSecSys 2.0

The Database of Burkholderia Secretion Systems 2.0 (DBSecSys 2.0) contains a curated set of 204 Burkholderia mallei (strain ATCC 23344) and 281 Burkholderia pseudomallei (strain K96243) proteins, which are either associated with 5 secretion systems or are known to be secreted but their secretion system type is undetermined. For these proteins, 170 B. mallei proteins are associated with 12 inferred pathogen mechanisms of action and 179 B. pseudomallei proteins are associated with 13 inferred pathogen mechanisms of action. Additionally, DBSecSys 2.0 contains more than 4,500 host-pathogen interactions between human/murine proteins and bacterial proteins associated with secretion systems.伯克霍尔德菌分泌系统数据库2.0（Database of Burkholderia Secretion Systems 2.0，缩写DBSecSys 2.0）收录了经人工遴选整理的204种鼻疽伯克霍尔德菌（菌株ATCC 23344）与281种类鼻疽伯克霍尔德菌（菌株K96243）的蛋白质。这些蛋白质要么与5种分泌系统相关联，要么已被证实具有分泌特性但尚未明确其所属分泌系统类型。针对上述蛋白质，170种鼻疽伯克霍尔德菌蛋白质与12种推测的病原体作用机制相关联，179种类鼻疽伯克霍尔德菌蛋白质则与13种推测的病原体作用机制相关联。此外，DBSecSys 2.0还收录了超过4500条人类/小鼠蛋白质与分泌系统相关细菌蛋白质之间的宿主-病原体相互作用数据。

搜集汇总

背景与挑战

背景概述

DBSecSys 2.0是一个关于伯克霍尔德菌分泌系统的数据库，包含485个伯克霍尔德菌蛋白质的精选数据，涉及5种分泌系统。该数据集还收录了超过4500个宿主-病原体相互作用信息，并关联了细菌蛋白质的致病机制。