Engineering a NIR-II Fluorescence/Photoacoustic Imaging Nano Phototherapy Reagent for Combined Photodynamic and Photothermal Therapies for Tumor

Photodynamic therapy (PDT) and photothermal
therapy (PTT),
as two
advanced noninvasive optical therapeutic strategies, have attracted
considerable attention for their high spatiotemporal selectivity and
minimal side effects. However, most existing synergistic therapeutic
systems rely on multicomponent nanocomposites, whose complex design
and preparation as well as cumbersome operation severely limit their
application. Therefore, developing single-component therapeutic agents
capable of synergistically achieving both PDT and PTT under a single
excitation wavelength has emerged as a frontier and core challenge
in this field. Herein, a 1,4-diethyldecahydroquinoline ring was introduced
into the cyanine backbone structure to construct a novel phototherapeutic
agent, IR805, with good stability and both PDT and PTT functions.
Importantly, the nanomodified NanoIR805-PEG nanoparticles could effectively
kill tumor cells or eliminate tumors in both in vitro and in vivo
antitumor processes. This study will provide new ideas and insights
into constructing new types of phototherapeutic agents with both PDT
and PTT functions.