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Total Synthesis of Chlorocyclinone A, a PPAR‑γ Antagonist

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NIAID Data Ecosystem2026-03-07 收录
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The first total synthesis of chlorocyclinone A (1) is regioselectively completed in 28 steps. The key steps are Pd-catalyzed methoxycarbonylation, unprecedented Hauser annulation, Krohn photo-oxidation, and regioselective gem-dichlorination.

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2012-11-16
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