Histone H4 is increased in SARS-CoV-2-infected lung epithelial cells and linked to COVID-19 severity

We found that histone H4 is a potential biomarker of COVID-19 pathogenesis. Bulk RNA-sequencing of endothelial cell samples from idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) patients as well as controls was used in addition to published sequencing data from peripheral blood mononuclear cells or bronchoalveolar lavage fluid cells from COVID-19 and IPF patients as well as controls. Transcriptome sequencing of control, IPF, and COPD endothelial cells