Copper-Catalyzed Multicomponent Domino Reaction of 2‑Bromoaldehydes, Benzylamines, and Sodium Azide for the Assembly of Quinazoline Derivatives
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An efficient three-component domino reaction of 2-bromoaldehydes, benzylamines, and sodium azide has been developed for the synthesis of quinazoline derivatives. This domino process involves copper-catalyzed SNAr, oxidation/cyclization, and denitrogenation sequences. The mild catalytic system enabled the effective construction of three C–N bonds in one operation.
创建时间：
2016-03-28
