Follicular lymphoma microenvironment characteristics associated with tumor cell mutations and MHC class II expression

Follicular lymphoma (FL) is a B-cell lymphoma with a complex tumor microenvironment that is rich in non-malignant immune cells. We applied single-cell RNA-sequencing to characterize the immune microenvironment of FL. This provides a classification framework of the FL microenvironment, their association with FL genotypes and antigen presentation, and informs different potential immunotherapeutic strategies. scRNA-seq of 20 FL lymph node biopsies and three reactive lymph nodes (RLN) using the 10X Chromium platform to profile the transcriptome in addition to T-cell receptor (TCR) and immunoglobulin (Ig) repertoires. **RAW data has been uploaded to EGA. Accession EGAS00001006052.**