Effects of A771726 in combination with LiCl on EV71- induced cytopathic effect.

CalcuSyn analysis provides combination index (CI) values to determine potential drug additivity in this Table. Inhibition of EV71 replication was evaluated in CPE test involving treatment with serial dilutions of A771726 (0, 0.625, 1.25, 2.5, 5 and 10 µM) or LiCl (0, 1.25, 2.5, 5, 10, 20 and 40 mM), or with a combination of the 2 compounds at fixed 2∶1 or 4∶1 ratios. The results show that A771726 combined with LiCl is synergistic, with CI values ranging from 0.20 to 0.49.Effects of A771726 in combination with LiCl on EV71- induced cytopathic effect.