TLR2-induced CD8+ T cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis

Sepsis is associated with profound immune dysregulation that increases the risk for life-threatening secondary infections: Dendritic cells (DCs) undergo functional reprogramming due to yet unknown changes during differentiation in the bone marrow (BM). We investigated whether T cells alter the gene expression in the bone marrow during sepsis using microarrays. CD8 T cells from wildtype or TLR2 ko mice were transferred into wildtype mice immediately before induction of sepsis by cecal ligation and puncture. After 24 h, bone marrow cells were isolated for RNA extraction and microarrays.