MissenseHMM: state-based annotations for missense variants through joint modeling of pathogenicity scores.

MissenseHMM: state-based annotations for missense variants through joint modeling of pathogenicity scores. This repository contains the v1 annotations trained from dbNSFP v5.0 on GRCh38. Pre-print: https://doi.org/10.64898/2026.01.31.703062. Source code can also be found at: https://github.com/ernstlab/MissenseHMM We note that some of the scores that are input to MissenseHMM and the dbNSFP database processing from which MissenseHMM annotations were derived restrict commercial applications without a license. For more information please refer to https://www.dbnsfp.org/license/.