Comparative genomics of Cryptosporidium parvum IIa and IId isolates. Cryptosporidium parvum

Zoonotic Cryptosporidium parvum infections are mainly caused by IIa and IId subtype families, which differ in host range. In this work, we evaluated the infection characteristics of one IIa isolate from the United States and four IId isolates from China in interferon gamma knockout (GKO) mice using qPCR to quantify oocyst shedding intensity and duration, histological examination to monitor pathological changes and genome-wide comparisons to identify isolate-specific differences.