Genome-wide profiling of early and late CD8 memory T cells expressing CD62L. Mus musculus

Memory CD8+ P14 cells were generarted through adoptive transfer and infection with LCMV armstrong. Then, early memory (after 30 - 45 days) and late memory (after 8 months) cells were sort purified based on CD62L expression. Genome-wide expression profiles were captured for early and late memory cells with high and low levels on CD62L using Affymetrics arrays to show their molecular and functional differences. Overall design: Replicates of early memory P14 cells that are CD62L-, early memory P14 cells that are CD62L+, late memory P14 cells that are CD62L-, and late memory P14 cells that are CD62L+ were analysed for differentially regulated genes and networks.