CAN displacement causes epidermal phenotypes that require signaling by specific Wnts and that resemble phenotypes caused by mutations in the Wnt-binding Ror/CAM-1 receptor.

aVulval fates: number of vulval progenitor cells adopting vulval fates. Wild-type is 3.00.bn: number of animals assayed.cp-Values were calculated using a two-tailed Student's t test.dMixed-stage animals were heat-shocked at 33°C for 45 min and scored 16 h later.eControl animals were of the same genotype as the transgenic animals, but lacked the extrachromosomal transgenic array.lf, loss-of-function.