Reconstruction of a partial pedigree from the MKK group.

We analyzed MKK genotype data using IBD analysis and inferred the familial relationships of 61 individuals with 46 being related to at least 1 other person. This graph contains relationships constructed from second-degree, full-sibling, parent-child, and identical relationships (with the exception of NA21352 and NA21351 who are inferred to be first-cousins based on their second-degree relationship to NA21414; see top left of figure). All indicated relationships are based on previous analysis (siblings: thick green lines), previous annotation (family trios; family ID), and inferred analyses (sibling relationships, thick blue lines; corrected parent-child orientation, thick red lines; corrections made to annotated relationships, thick yellow lines; other familial relationships; thin black lines). Dashed rectangles indicate family units annotated by the HapMap project at the Coriell website. F indicates family identifier (e.g. F2654). Individual identifiers are shown as the last three digits of NA21xxx (e.g. 353 at the upper left of the figure corresponds to individual NA21353). All IBD information is given in Table S1. Note that several individuals who are part of MKK (e.g. NA12310 in family 2566) and for whom cell lines were created did not have SNP data as part of the HapMap Phase III release.