Summary of lag times of SOD1 fibrillization for spontaneous and seeded reactions.

Fmax = average maximum fluorescence (arbitrary unit, a.u.), T0.5 = observed time at transition mid-point (hrs), lag time = incubation duration prior to increase in fluorescence corresponding to initiation of fibrillization (hrs), τ = 1/propagation rate of fibril growth (hrs). Data shown are average values from 6–10 replicates (± SEM) pooled from 2–3 independent assays.