Global mass spectrometry and transcriptomics array based drug profiling provides novel insight into glucosamine induced ER stress.

Data from ProteomeXchange, PXD ID: PXD000380. Experiment: Treatment, file: MS12236QE_rune_henrik_Treatment_c.mzml. Published as part of Mol Cell Proteomics. 2014 Aug 15 . From the Abstract: {{i}} We investigated the molecular effects of glucosamine supplements, a popular and safe alternative to non-steroidal anti-inflammatory drugs, for decreasing pain, inflammation and maintaining healthy joints. Numerous studies have reported an array of molecular effects after glucosamine treatment. We questioned whether the differences in the effects observed in previous studies were associated with the focus on a specific subproteome or with the use of specific cell lines or tissues. To address this question, global mass spectrometry- and transcription array-based glucosamine drug profiling was performed on malignant cell lines from different stages of lymphocyte development ... {{/i}}