The Translational Potential of Circulating circRNAs as Liquid Biopsy Biomarkers for Non-Cancerous Diseases

This dataset compiles the supporting information and evidence base for the comprehensive review entitled "The Translational Potential of Circulating circRNAs as Liquid Biopsy Biomarkers for Non-Cancerous Diseases".

What data contains:
The dataset includes curated literature analysis and synthesized data on the characteristics, mechanisms, and clinical applications of circular RNAs (circRNAs) as liquid biopsy biomarkers. It encompasses their roles in non-cancerous diseases, with a focus on Cardiovascular Diseases (e.g., Atherosclerosis, Myocardial Infarction, Heart Failure) and Autoimmune Diseases (e.g., Rheumatoid Arthritis, Systemic Lupus Erythematosus). Data on circRNA biogenesis, stability, function (e.g., as miRNA sponges), and detection technologies (e.g., RNA-Seq, qRT-PCR) are also included.

How data was gathered:
The data were systematically gathered from published peer-reviewed literature. The process involved identifying relevant studies, extracting key findings on circRNA expression, function, and diagnostic/therapeutic potential, and organizing them into a structured format to facilitate the analysis presented in the review.

Why this data is valuable:
This structured dataset provides the empirical foundation for the review's conclusions regarding the significant translational potential of circRNAs in non-cancerous diseases. It highlights the advantages of circRNAs over traditional biomarkers, including their high stability, tissue specificity, and presence in various biofluids. The dataset enables transparency, reproducibility, and serves as a valuable resource for researchers and clinicians interested in the development of novel non-invasive diagnostic and monitoring tools