Meta-analysis of human cortical snRNA-seq data

In this study, we collected and meta-analyzed ~3M nuclei transcriptomics from 22 published studies. Using canonical cell markers, we annotated all cell types of BICCN. We also mapped the cells to 10 age stages from first trimester to elder (60+ years). Integrating these snRNA-seq data with statistics of genome-wide association study (GWAS) , we tried to identify cell types associated with schizophrenia (SCZ) and bipolar disorder (BD) in different age stages.