Selection of probes demethylated after AZA or DAC treatments.

A, Schematic for classification of probes. Of 52,915 probes with low within-replicate variance, 2217 probes had mean log2-ratios larger than one in the control samples indicating more than 50% CG methylation. Probes whose between group variance was at least 0.5 times that of the sum of within group variances and whose log2-ratios was less than 1.0 after treatment were considered as demethylated. B, Distribution of gene feature classes within demethylated CGI probes. In mock-treated cells, the percentage of methylated probes in each class (log2-ratios higher than 1.0, 2217 probes) is shown. Demethylated probes were over-represented in promoters (p