First Degree Relatives (FDRs) of Patients with Celiac Disease Harbour an Intestinal Transcriptomic Signature that Might Protect Them from Enterocyte Damage

Patients with Celiac Disease, first degree relatives of celiac patients and control groups displayed significant differential gene expression. All subjects were underwent upper GI endoscopic examination. Multiple mucosal biopsies were obtained using spike biopsy forceps. Four bits of tissues in 10% formal saline were sent for histological assessment for villous architecture assessment. Other 4-6 bites of mucosal biopsies were taken in RNA later for gene expression analysis. In this study, FDRs were selected randomly and none of the FDRs were related to Celiac patients.