Effects of high cholesterol diet on intimal transcriptome [Intima_mRNA]. Effects of high cholesterol diet on intimal transcriptome [Intima_mRNA]

Purpose: To investigate the effects of high cholesterol diet on the intimal transcriptome related to atherosclerosis. Methods: 3-week-old LDLR-/- male mice were fed a high cholesterol or low cholesterol diet for 9 weeks. Intimal RNA was extracted by injecting Trizol into the aorta and collecting the flow through for further processing. Results: Mice fed a high cholesterol revealed upregulation in atherosclerosis and immune/inflammatory related genes. Overall design: Intimal mRNA and small RNA were sequenced from LDLR-/- male mice after 9 weeks of low cholesterol or high cholesterol feeding. This dataset includes the intimal mRNA data.