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Evolution of the human proteome: Completing the Chordate Nodes

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NIAID Data Ecosystem2026-03-07 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA176378
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The overarching goal of this proposal is to assemble comparative genomic data to enable stepwise reconstruction of the evolution of the human proteome. This involves tracing every human gene back to its progenitor genes or modules, at each stage of its ancestry, from mammals to the first multicellular animals. These data will then enable resolution of a fundamental question: how has the evolution and deployment of new proteins, as well as expansion of protein families, contributed to each evolutionary step in human ancestry?
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2012-10-01
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