Effects of targeted overexpression of OA overexpression in osteoclastic cells on histomorphometric bone formation parameters in 8-week-old male OA-Tg and also in 15.3-week-old female OA-Tg mice (mean±SEM).

BS, bone surface; TLS, tetracycline labeling surface; MAR, mineralization apposition rate; BFR, bone formation rate; E.BS, endosteal bone surface; E.TLS, endosteal tetracycline labeling surface; E.MAR, endosteal mineralization apposition rate; E.BFR, endosteal bone formation rate.*Dynamic bone formation parameters were performed on longitudinal sections of femurs of 7 WT littermates and 13 OA-Tg mice at the cortical bone site of the mid-shaft, starting from 1.2 mm from the lowest point, 2 grids under a 10× microscope lens.#Dynamic bone formation parameters were performed on the endosteal surface of femurs of 8 WT littermates and 11 OA-Tg mice.