Genomic, transcriptomic and epigenomic profiling of GCTB
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https://www.omicsdi.org/dataset/ega/EGAS00001003730
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资源简介：
Giant cell tumor of bone is a rare bone neoplasm driven by oncogenic hotspot G34W/L/V mutations in the non-canonical histone variant H3.3. This study provides primary data of genomic (WGS), transcriptomic (RNA-seq) and epigenomic (histone mark ChIP-seq, WGBS, ATAC-seq) profiling of primary GCTB samples from several cohorts in Germany and Korea. We confirm the H3.3-G34 mutations as sole genetic drivers of GCTB, and describe the epigenetic alterations in mutant GCTB stromal cells.EGA study EGAS00001003730
创建时间：
2020-09-04
